Broad- and narrow-spectrum antibiotics: a different approach
نویسندگان
چکیده
منابع مشابه
Antimicrobial peptides: broad-spectrum antibiotics from nature.
No therapeutically useful new classes of antibiotics have been identified in the past quarter of a century This has become of major consequence in the face of the increase in the incidence of significant antibiotic resistance in the past decade. Indeed, strains of several important pathogens have been identified for which very few, or even no, possibilities for antibiotic therapy exist. Althoug...
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Membrane-permeabilizing peptide antibiotics are an underutilized weapon in the battle against drug-resistant microorganisms. This is true, in part, because of the bottleneck caused by the lack of explicit design principles and the paucity of simple high-throughput methods for selection. In this work, we characterize the requirements for broad-spectrum antimicrobial activity by membrane permeabi...
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Antibiotic adjuvant therapy represents an exciting opportunity to enhance the activity of clinical antibiotics by co-dosing with a secondary small molecule. Successful adjuvants decrease the concentration of antibiotics used to defeat bacteria, increase activity (in some cases introducing activity against organisms that are drug resistant), and reduce the frequency at which drug-resistant bacte...
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background and objective: nanoscopic life forms called nanobacteria or calcifying nanoparticles (cnp) are unconventional agents. these novel organisms are very small (0.1 to 0.5 microns) and possess unusual properties such as high resistance to heat and routine antimicrobial agents. nanobacteria are 100 times smaller than bacteria and protected by a shell of apatite, so they could be as candida...
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Nuclear medicine imaging has been used to localize infection sites and efforts have been continued to develop modified infection specific radiopharmaceuticals. In this study gemifloxacin as a broad-spectrum quinolone has been labeled with [99mTc (CO)3 (H2O)3]+ core in order to evaluate its feasibility as an infection imaging agent for in vivo use. The stability of radioconjugate was checked in ...
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ژورنال
عنوان ژورنال: Clinical Microbiology and Infection
سال: 1998
ISSN: 1198-743X
DOI: 10.1111/j.1469-0691.1998.tb00338.x